MYSP-2023-041

陳修平


下載導師簡歷CV
Section 1: Personal Particulars

陳修平
Xiuping Chen
Professor
88224679
xpchen@um.edu.mo
University of Macau
UMAC-SKL of Quality Research in Chinese Medicine
https://sklqrcm.um.edu.mo/xiu-ping-chen/

Research Project provided for Macao Youth Scholars Program:

丹參酮協同NQO1生物激活藥物抗腫瘤分子機制與新藥研發
Mechanistic and translational study on the synergistic activity of cryptotanshinone combined with NQO1 bioactivatable drugs in cancer
1007 药学
0202 应用经济学,0702 物理学,0703 化学,0704 天文学,0705 地理学,0707 海洋科学,0708 地球物理学,0709 地质学,0710 生物学,0713 生态学,0802 机械工程,0803 光学工程,0805 材料科学与工程,0807 动力工程及工程热物理,0808 电气工程,0809 电子科学与技术,0810 信息与通信工程,0811 控制科学与工程,0814 土木工程,0827 核科学与技术,0831 生物医学工程,1001 基础医学,1004 公共卫生与预防医学,1007 药学,1008 中药学

Section 2: Research Interests and Grants

Preclinical study of natural products regulating programmed cell death We mainly focuses on the preclinical development of naturals products that regulate programmed cell death (PCD). By using integrated platforms, we have identified naturals products with distinct mechanisms of action to induced PCD. We demonstrate that 2-methoxy-6-acetyl-7-methyljuglone (MAM), a type of quinone, induce cell-type dependent PCD dependent on ROS, caspase, RIPK1, or NQO1. We report for the first time that the form of PCD induced by MAM is distinct to any other types of PCD reported, and highly dependent on NQO1-mediated ROS production. We term this novel type of PCD as noptosis. We are still working on the underlying mechanisms and signaling that lead to noptosis. The therapetutic potential of noptosis is also being explored. Development of epithelial-mesenchymal transition inhibitors Epithelial-mesenchymal transition (EMT) is of pivotal importance in controlling tumor metastasis and organ fibrosis.
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Mechanistic and translational study on the synergistic activity of cryptotanshinone combined with NQO1 bioactivatable drugs in cancer, FDCT,0070/2022/A2,2,234,000MOP,2022.12-2025.12