導師資訊

University of Macau

UMAC-SKL of Quality Research in Chinese Medicine

https://sklqrcm.um.edu.mo/de-fang-ouyang/

藥物傳遞的多尺度模擬

Multiscale-modeling in drug delivery

1008 中药学

1007 药学

Previous experiences on computer modeling

PhD

Prof. Ouyang is a recognized leader in the computational pharmaceutics field and the founding chair of the Computational Pharmacy Society (CPhS). He has published 2 books, 6 book chapters, over 100 peer-reviewed papers (e.g. Acta Pharmaceutica Sinica B, Journal of Controlled Release, Biomaterials et al.), and over 100 invited presentations (e.g. US-FDA). He had been granted 11 patents, which had been used in marketed pharmaceutical products. He edited the first book (John Wiley & Sons Inc., 2015, as shown above) in this research area. He serves as the associate editor/editorial board of multiple SCI journals, such as , , , and . He successfully attracted 11 research grants (over 20 million MOP in total) in the past 6 years. He established the first global artificial intelligence (AI)-based formulation platform (https://formulationai.computpharm.org/), which attracts widely global users (e.g. Boehringer Ingelheim, Triastek and other companies). He successfully supervised over 30 PhD and master students. He built wide networks with industry, business, government agencies and professional bodies in the world.

Since 2011, Prof. Ouyang has pioneered the integration of artificial intelligence, big data and multi-scale modeling techniques in the field of drug/gene delivery - "computational pharmaceutics”: • Artificial intelligence (AI) for pharmaceutics: to develop novel machine learning algorithms for the prediction of pharmaceutical formulations, such as lipid nanoparticle (LNP) for mRNA/siRNA delivery, long-term sustained release microsphere and various solubilization techniques for water insoluble drugs; • Multi-scale modeling in drug/gene delivery: to integrate quantum mechanics (QM), molecular dynamics (MD), mathematical modeling and physiologically based pharmacokinetic (PBPK) modeling into drug and gene delivery systems; • Pharmacoinformatics: big data analysis of pharmaceutical information from the literature, patent, clinical trial and marketed products.

10

7

2

“Investigation of the release mechanism of long-sustained release microspheres”, University of Macau Research Grant (MYRG-CRG2022-00008-ICMS), 1,520,000 MOP, Macau (PI), 2 years.