導師資訊

University of Macau

UMAC-Institute of Collaborative Innovation

Associate Dean of ICI

https://scholar.google.com/citations?hl=en&user=3yoS6wYAAAAJ&view_op=list_works&sortby=pubdate

可穿戴近红外光谱脑功能成像介导的经颅光生物调节干预抑郁症关键技术研究

The Key Technologies for wearable fNIRS neuroimaging-guided photomodulation of depression

0831 生物医学工程

0202 应用经济学,0702 物理学,0703 化学,0704 天文学,0705 地理学,0707 海洋科学,0708 地球物理学,0709 地质学,0713 生态学,0802 机械工程,0803 光学工程,0805 材料科学与工程,0807 动力工程及工程热物理,0808 电气工程,0809 电子科学与技术,0810 信息与通信工程,0811 控制科学与工程,0814 土木工程,0831 生物医学工程,1001 基础医学,1004 公共卫生与预防医学,1007 药学,1008 中药学

Biomedical optics, neuroscience, molecular imaging, neuroimaging

Personal Particulars Programme Coordinators, Centre for Cognitive and Brain Sciences, Institute of Collaborative Innovation, University of Macau Professional Services  Senior Member of SPIE (since 2008)  Senior Member of OSA (since 2010)  Committee Member of China Optical Society  Committee Member of China Biomedical Optics Society  Committee Members of China Biomedical Engineering Society  Committee Members of 中國解剖協會  Vice Chair, Macau Society of Nuclear Medicine and Molecular Imaging  2020-now, 副主席（Vice Chair） 澳門超分子化學與生物材料學會 Research Interests Neurophotonics and Neuroscience  Neuroimaging and Brain Connectome  Functional Near Infrared Spectroscopy (fNIRS);  Brain Disorders and Cognitive Neuroscience;  Optogenetics, Brain Intervention and Photomodulation Biomedical Optics and Optical Molecular Imaging  Diffuse Optical Tomography(DOT);  Photoacoustic Tomography/Photoacoustic Microscopy (PAT and PAM);  Fluorescent Imaging;  Optical Coherence Tomography(OCT);  Photothermal and Photodynamic Therapy;  Molecular Imaging and Cancer Nanomedicine. Teaching Interests • Biomedical Optics; • Neuroscience and Neurodegenerative Diseases; • Biomedical Imaging; • Advanced Biomedical and Chemical Engineering. Editorial Board/Associate Editor  Senior Associate Editor of BMC Medical Imaging  Editor of Journal of Innovative Optical Health Sciences  Associate Editor of Frontiers in Human Neuroscience  Editorial Member of Quantitative Imaging in Medicine and Surgery  Editorial Member of Bio Integration  Special issue Editor for Biomedical Research International  Special issue Editor for Journal of Innovative Optical Health Sciences  Special issue Editor for Frontiers in Human Neuroscience  Special issue Editor for Frontiers in Psychology  Special issue Editor for Biomed Research International Grant Review (selected)  BRAIN Initiative R21, NIH/NEI, US  L'Agence Nationale de la Recherche, France  External grant reviewer for Science Foundation of Czech Republic, Czech  Brain Peer Review Committee, the American Heart Association, US  External grant reviewer for Israel Science Foundation, Israel  NIH: BMIT: "Biomedical Imaging Technology", US  NIH: SBMI : "Small Business Medical Imaging" , US  External grant reviewer for Australia National Science Foundation, Australia  External grant reviewer for China National Science Foundation, China  External grant reviewer for Guangdong Province Science Foundation, China  External grant reviewer for Key Projects of MOST, PRC, China  NIH: NIDA Cutting-Edge Basic Research Awards R21 panel, US  External reviewer of University Fund for Nanyang Technological University, Singapore Journal Reviewer (selected)  ACS Nano, Nano Letters, Theranostics, Advanced Functional Materials, Advanced Materials, ACS Applied Materials and Interfaces, JACS, Biomaterials, Advanced Science  Optics Letters, Optics Express, Journal of Biophotonics, IEEE Transaction on Biomedical Engineering, Applied Physics Letters, Medical Physics  Neuroimage, Human brain Mapping, Brain, Journal of Neuroscience, Behavioral Research and Therapy, Brain Structure and Functions, Neural Networks, eNeuron  National Science Review, PNAS, eLife, Nature Photonics, Nature Biomedical Engineering, Nature Communication, Science Advances, Neuron Patents  Hybrid Photoacoustic Tomography (PAT) and Diffuse Optical Tomography (DOT): Methods and Algorithms, US patent No. PCT/US2008/055894.  METHOD AND APPARATUS FOR TOMOGRAPHIC IMAGING OF ABSOLUTE OPTICAL ABSORPTION COEFFICIENT IN TURBID MEDIA USING COMBINED PHOTOACOUSTIC AND DIFFUSING LIGHT MEASUREMENTS US PATENT: WO/2009/011934  一種融合光聲顯微，螢光顯微和超聲成像於一體的多模態顯微成像系統。中國專利號: 201820951744.5. Research Grants in the University of Macau (UM) Present Grants as Principal Investigator in UM (Over 16,000,000 MOP)  2022-2024-The Key Technologies for wearable fNIRS neuroimaging-guided photomodulation of depression, 1300000MOP. FDCT 0048/2021/AGJ澳門科學技術發展基金-广东省重大项目 联合项目  2020-2023-Dual-modal photoacoustic and ultrasound imaging-guided cancer phototherapy with bacteria as the multifunctional theranostics agent， 1100000MOP. FDCT 0020/2019/AMJ:澳門科學技術發展基金-科技部重大项目 联合项目  2022-2024-Development and application of a three-dimensional visualization surgical navigation system for the spine based on mixed reality. EF011/FHS-YZ/2022/ZHSTI, 1M RMB, The Key Project of Zhuhai City （珠海市重大科研專案）.  2023-2025- Biomimetic Liposomes Delivered by Meningeal Lymphatic Vessels for Synergistic Therapy of Parkinson's Disease. MOP 320,000 →MYRG2022-00054-FHS → 澳門大學多年度研究資助.  2021-2024-多模态脑功能影像引导的经颅磁刺激早期干预小儿唐氏综合征， RMB-100,000→2020 Natural Science Foundation of Guangdong Province  2021-2023- Dual-modal optical coherence tomography and photoacoustic imaging-guided dose-control cancer chemotherapy in the second near-infrared window, MOP 560,000 →MYRG2020-00067-FHS → 澳門大學多年度研究資助  2020-2023- Dual-modal photoacoustic and ultrasound imaging-guided cancer phototherapy with bacteria as the multifunctional theranostics agent, MOP 1,200,000→ FDCT 0020/2019/AMJ→ 澳門科學技術發展基金研究資助  2018-2021- Photoacoustic Molecular Imaging and Functional Neuroimaging Guided Photodynamic Therapy of Brain Glioma, MOP 1,800,000→ FDCT 0011/2018/A1 → 澳門科學技術發展基金研究資助  2019-2021- NIR-II light-responsive oxygen-independent hybrid nanoplatform for multiscale photoacoustic imaging-guided photothermal/photodynamic synergistic cancer therapy, MOP 750,000→ MYRG2019-00082-FHS → 澳門大學多年度研究資助  2018-2021- Development of quantitative multispectral photoacoustic elastic tomography for clinical detection of early-stage scleroderma, MOP 900,000→ MYRG2018-00081-FHS → 澳門大學多年度研究資助  2015-2018- Monitoring Responses to Neoadjuvant Chemotherapy in Breast Cancer Using Quantitative Photoacoustic Spectroscopy Imaging-使用定量的光声 譜成像監測乳腺癌對新輔助化療的反應, MOP 2,000,000→MYRG2015-00036-FHS→ 澳門大學多年度研究資助  2016-2019- Structural and functional in vivo imaging of the bone-implant systems by multiscale photoacoustic tomography-使用多尺度光聲斷層成像實現骨- 植入物系統的活體結構和功能成像, MOP 1,310,000→ MYRG2016-00110-FHS → 澳門大學多年度研究資助  2014-2017 - Photoacoustic Imaging of Binding Rate of Nanoparticles in Cancer Nanomedicine - 光聲成像癌症納米探針的結合率, MOP 500,000 →MYRG2014-00093-FHS → 澳門大學多年度研究資助  2015-2018 - Development of Functional Multimodal Optical Imaging Techniques for Clinical Screening of Breast Cancer -基於乳腺癌臨床篩選的多功能光學成像技術的研究MOP 1,780,000 → FDCT 026/2014/A1→ 澳門科學技術發展基金研究資助  2016-2019 - Using fused EEG and fNIRS to Study the Efficacy of Physical Therapy on Cerebral Palsy -使用融合的腦電和近紅外光譜成像研究運動療法治療腦癱的效果 MOP 2,200,000 → FDCT 025/2015/A1 → 澳門科學技術發展基金研究資助  2015-2018 - Development of Functional Multimodal Optical Imaging Techniques for Clinical Screening of Breast Cancer -基於乳腺癌臨床篩選的多功能光學成像技術的研究MOP 600,000 → UM MRG →澳門大學多年度研究資助  2013-2014 - Identifying the Cortical Network Dynamics of Gambling Disorders in the Human Brains Using fNIRS Measurements-使用近紅外光譜測量識別人腦賭癮的神經網絡動力MOP 100,000 → UM SRG → 澳門大學新職員啟動研究資助  2016-2019 - Using fused EEG and fNIRS to Study the Efficacy of Physical Therapy on Cerebral Palsy -使用融合的腦電和近紅外光譜成像研究運動療法治療腦癱的效果 MOP 700,000 → UM MRG →澳門大學多年度研究資助 Awards  2016年中國光學重大成果獎  2017 FHS Best Teacher Award in Research

Research Interests Neurophotonics and Neuroscience  Neuroimaging and Brain Connectome  Functional Near Infrared Spectroscopy (fNIRS);  Brain Disorders and Cognitive Neuroscience;  Optogenetics, Brain Intervention and Photomodulation Biomedical Optics and Optical Molecular Imaging  Diffuse Optical Tomography(DOT);  Photoacoustic Tomography/Photoacoustic Microscopy (PAT and PAM);  Fluorescent Imaging;  Optical Coherence Tomography(OCT);  Photothermal and Photodynamic Therapy;  Molecular Imaging and Cancer Nanomedicine.

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Research Grants in the University of Macau (UM)
Present Grants as Principal Investigator in UM (Over 16,000,000 MOP)

 2022-2024-The Key Technologies for wearable fNIRS neuroimaging-guided photomodulation of depression, 1300000MOP. FDCT 0048/2021/AGJ澳門科學技術發展基金-广东省重大项目 联合项目

 2020-2023-Dual-modal photoacoustic and ultrasound imaging-guided cancer phototherapy with bacteria as the multifunctional theranostics agent， 1100000MOP. FDCT 0020/2019/AMJ:澳門科學技術發展基金-科技部重大项目 联合项目

 2022-2024-Development and application of a three-dimensional visualization surgical navigation system for the spine based on mixed reality. EF011/FHS-YZ/2022/ZHSTI, 1M RMB, The Key Project of Zhuhai City （珠海市重大科研專案）.

 2023-2025- Biomimetic Liposomes Delivered by Meningeal Lymphatic Vessels for Synergistic Therapy of Parkinson's Disease. MOP 320,000 →MYRG2022-00054-FHS → 澳門大學多年度研究資助.

 2021-2024-多模态脑功能影像引导的经颅磁刺激早期干预小儿唐氏综合征， RMB-100,000→2020 Natural Science Foundation of Guangdong Province

 2021-2023- Dual-modal optical coherence tomography and photoacoustic imaging-guided dose-control cancer chemotherapy in the second near-infrared window, MOP 560,000 →MYRG2020-00067-FHS → 澳門大學多年度研究資助

 2020-2023- Dual-modal photoacoustic and ultrasound imaging-guided cancer phototherapy with bacteria as the multifunctional theranostics agent, MOP 1,200,000→ FDCT 0020/2019/AMJ→ 澳門科學技術發展基金研究資助

 2018-2021- Photoacoustic Molecular Imaging and Functional Neuroimaging Guided Photodynamic Therapy of Brain Glioma, MOP 1,800,000→ FDCT 0011/2018/A1 → 澳門科學技術發展基金研究資助

 2019-2021- NIR-II light-responsive oxygen-independent hybrid nanoplatform for multiscale photoacoustic imaging-guided photothermal/photodynamic synergistic cancer therapy, MOP 750,000→ MYRG2019-00082-FHS → 澳門大學多年度研究資助

 2018-2021- Development of quantitative multispectral photoacoustic elastic tomography for clinical detection of early-stage scleroderma, MOP 900,000→ MYRG2018-00081-FHS → 澳門大學多年度研究資助

 2015-2018- Monitoring Responses to Neoadjuvant Chemotherapy in Breast
Cancer Using Quantitative Photoacoustic Spectroscopy Imaging-使用定量的光声 譜成像監測乳腺癌對新輔助化療的反應, MOP 2,000,000→MYRG2015-00036-FHS→ 澳門大學多年度研究資助

 2016-2019- Structural and functional in vivo imaging of the bone-implant systems by multiscale photoacoustic tomography-使用多尺度光聲斷層成像實現骨- 植入物系統的活體結構和功能成像, MOP 1,310,000→ MYRG2016-00110-FHS → 澳門大學多年度研究資助

 2014-2017 - Photoacoustic Imaging of Binding Rate of Nanoparticles in Cancer Nanomedicine - 光聲成像癌症納米探針的結合率, MOP 500,000 →MYRG2014-00093-FHS → 澳門大學多年度研究資助

 2015-2018 - Development of Functional Multimodal Optical Imaging Techniques for Clinical Screening of Breast Cancer -基於乳腺癌臨床篩選的多功能光學成像技術的研究MOP 1,780,000 → FDCT 026/2014/A1→ 澳門科學技術發展基金研究資助

 2016-2019 - Using fused EEG and fNIRS to Study the Efficacy of Physical Therapy on Cerebral Palsy -使用融合的腦電和近紅外光譜成像研究運動療法治療腦癱的效果 MOP 2,200,000 → FDCT 025/2015/A1 → 澳門科學技術發展基金研究資助

 2015-2018 - Development of Functional Multimodal Optical Imaging Techniques for Clinical Screening of Breast Cancer -基於乳腺癌臨床篩選的多功能光學成像技術的研究MOP 600,000 → UM MRG →澳門大學多年度研究資助

 2013-2014 - Identifying the Cortical Network Dynamics of Gambling Disorders in the Human Brains Using fNIRS Measurements-使用近紅外光譜測量識別人腦賭癮的神經網絡動力MOP 100,000 → UM SRG → 澳門大學新職員啟動研究資助

 2016-2019 - Using fused EEG and fNIRS to Study the Efficacy of Physical Therapy on Cerebral Palsy -使用融合的腦電和近紅外光譜成像研究運動療法治療腦癱的效果 MOP 700,000 → UM MRG →澳門大學多年度研究資助

Awards
 2016年中國光學重大成果獎
 2017 FHS Best Teacher Award in Research